Drug dosage for microneedle?based transdermal drug delivery systems utilizing evaporation?induced droplet transport
Sprache des Titels:
We present a setup for directed loading of standard microneedle arrays for transdermal drug delivery with the respective
therapeutic agent. The necessity to dose medical drugs according to their particular utilization requires an exact volumetric
measure of the particular drug, which is usually provided as a liquid. This is achieved by arranging a metallic plate above
the array featuring a set of holes aligned with the microneedles underneath. The plate is coated with a superhydrophobic
layer. To initiate the filling, droplets are deposited on said holes, where the volume needs to be above the desired load for an
individual needle, but the exact dosage is not required. Evaporation of these sessile droplets, after some time, leads to the
falling of the droplets through the microfluidic plate, delivering an exact amount of liquid drug to the needles underneath.
The proposed setup is easy to implement and parallelize, assisting in the task of accurate and high throughput coating of
microneedle-based transdermal drug delivery devices.