Asymmetrically substituted cationic porphyrins inhibit tumor proliferation in small intestinal neuroendocrine tumors and medullary thyroid carcinomas
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MEN2010 - International workshop on multiple endocrine neoplasia
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Cationic porphyrins represent an expanding class of compounds, which have several applications in biology, medicine and catalysis and have been studied from the viewpoint of their role as DNA cleavers.
Recent studies about the interaction of cationic porphyrins and their derivatives with DNA have moved porphyrin compounds into the spotlight of an alternative anticancer strategy.
In this work we present the synthesis of the fully water soluble cationic porphyrins TMPy3PhenEDTA-P-Cl4(1), TMPy3PhenIndolprot1P?Cl3 and TMPy3Py-Fluorenyl1P?Cl4 functionalized with EDTA, indole or fluorene moieties. Antiproliferative effects were evaluated in the small intestinal neuroendocrine tumor (SI-NET) cell line KRJ-I, the medullary thyroid carcinoma (MTC) cell line MTC-SK and the human fibroblast cell line HF-SAR.