In the past few years, HPS and STS scholars have investigated the nature of bioinformatics. These works have thoroughly documented how bioinformatics tools have become essential to manage and organize the recent data explosion that has overwhelmed biology. However, this emphasis on data management is also a limit of this literature, because it reduces bioinformatics to a set of computational tools that provides mere support to wet-lab biologists (e.g. databases). But bioinformatics is not just data management; it is also a set of computational tools to do (in-silico) experiments. What does it mean for bioinformatics to do biological experiments? How do these experiments differ from traditional, material experiments? What is the epistemic role played by technology in material and bioinformatics experiments in the context of molecular biology?