Electrochromic shift calculations reveal spectral tuning in animal rhodopsins
Sprache des Vortragstitels:
80. Jahrestagung der DPG und DPG-Frühjahrstagung
Sprache des Tagungstitel:
Rhodopsins are biological pigment-protein complexes found in photoreceptor cells of the retina. Within the framework of a two-step quantum chemical/electrostatic calculation scheme  that has recently been successfully applied to reveal the functional states of BLUF photoreceptors , we estimated absorption shifts of the retinal chromophore for a series of site-directed mutants. We eventually explain the variations of the maximal absorbance in the red- and green-sensitive visual pigments. Our results are in excellent agreement with recent experimental studies  and suggest that the maximum spectral sensitivity in animal rhodopsins is dominated by electrostatic tuning.
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