Numerical (CFD) simulation of polymer-drug distribution during injection moulding using OpenFOAM and SIGMASOFT
Sprache des Vortragstitels:
Austrian-Slovenian Polymer Meeting (ASPM) 2013
Sprache des Tagungstitel:
40% of all active pharmaceutical ingredients (APIs) can be considered
poorly water soluble. New processes and formulations need to be
developed to enhance the bioavailability of such substances. Injection moulding technique is used to fabricate drug dosage forms with enhanced solubility. The distribution homogeneity of the drug within the polymer matrix must be ensured by the end of the injection moulding process. The posterpresentation gives an overview of the CFD set-up for an amorphous solid dispersion of the plasticizer unit and the tablet injection mould.