Anna Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Martin Ring, Leopold Schmetterer, Matthias Bolz,
"Effects of Three Intravitreal Injections of Aflibercept on the Ocular Circulation in Eyes With Age-Related MaculopathyEffects of Three Intravitreal Injections of Aflibercept on the Ocular Circulation in Eyes With Age-Related Maculopathy"
, in British Journal of Ophthalmology, Vol. 104(1), BMJ Publishing Group UK, Seite(n) 53-57, 2021, ISSN: 1468-2079
Original Titel:
Effects of Three Intravitreal Injections of Aflibercept on the Ocular Circulation in Eyes With Age-Related MaculopathyEffects of Three Intravitreal Injections of Aflibercept on the Ocular Circulation in Eyes With Age-Related Maculopathy
Sprache des Titels:
Englisch
Original Kurzfassung:
Abstract
Aims: To investigate changes in ocular perfusion following three consecutive intravitreal injections with aflibercept for treatment of neovascular age-related macular degeneration (nAMD).
Methods: The study included 20 eyes from 20 Caucasian patients with unilateral nAMD and 20 fellow eyes. All nAMD eyes were treated with standard intravitreal injection of aflibercept (IVA; 2 mg). Measurements of ocular perfusion at the optic nerve head (ONH) and the choroid were performed with laser speckle flowgraphy (LSFG). Measurements were conducted at baseline, 1 week after the first injection, at the time point of the second and third injection as well as 1 month after the third injection.
Results: In treated eyes, mean blur rate (the main output parameter of LSFG) in the ONH microvasculature and in the choroid was significantly reduced 1 week after the first IVA treatment. The effect persisted throughout the entire follow-up period (p<0.001). No change in ocular perfusion was observed in fellow eyes.
Conclusions: IVA for treatment of nAMD leads to a reduction in perfusion of the ONH and the choroid in the treated eye with no apparent effect on the fellow eye.
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