Stefan Aichhorn, Anne Linhardt, Markus Nadlinger, Ian Teasdale, Wolfgang Schöfberger,
"Cover Feature: A pH?sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier"
, in Chemistry - A European Journal, Vol. 23, Nummer 70, Wiley Online Libary, Seite(n) 17624, 10-2017, ISSN: 0947-6539
Original Titel:
Cover Feature: A pH?sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier
Sprache des Titels:
Englisch
Original Kurzfassung:
The chemical synthesis and biological activity of new functionalized imidazoquinoline derivatives (ImQ) to generate Toll?like receptor (TLR) 7/8 specific prodrugs are presented. In vivo activity of ImQs to induce inflammation was confirmed in zebrafish larvae. After covalent ligation to fully biodegradable polyphosphazenes (ImQ?polymer), the macromolecular prodrugs were designed to undergo intracellular pH?sensitive release of ImQs to induce inflammation through binding to endosomal TLR7/8. More information can be found in the Full Paper by M.?Distel, A.?Dohnal, I.?Teasdale, W.? Schöfberger et?al. on page 17721.
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