Iron-Catalyzed Cyclotrimerization of Terminal Alkynes by Dual Catalyst Activation in the Absence of Reductants
Sprache des Titels:
Englisch
Original Kurzfassung:
Catalyzing C-C bond-forming reactions with earthabundant
metals under mild conditions is at the heart of
sustainable synthesis. The cyclotrimerization of alkynes is
a valuable atom-efficient reaction in organic synthesis that is
enabled by several metal catalysts, including iron. This study
reports an effective iron-catalyzed cyclotrimerization for the
regioselective synthesis of 1,2,4-substituted arenes (1 mol%
catalyst, toluene, 20°C, 5 min). A dual activation mechanism
(substrate deprotonation, reductive elimination) renders the
simple FeII precatalyst highly active in the absence of any
reductant.