Molecular Recognition Force Spectroscopy: A New Tool to Tailor Targeted Nanoparticles
Sprache des Titels:
Englisch
Original Kurzfassung:
The density of targeting moieties in a nanoparticle-based gene-delivery system has been shown to play a fundamental role in its vectoring performance. Here, molecular recognition force spectroscopy is proposed as a novel screening tool to optimize the density of targeting moieties of functionalized nanoparticles towards attaining cell-specific interaction. By tailoring the nanoparticle formulation, the unbinding event probability between nanoparticles tethered to an atomic force microscopy tip and neuronal cells is directly correlated to the nanoparticle gene-vectoring capacity. Additionally, new insights into protein?receptor interaction are revealed. This novel approach opens new avenues in the field of nanomedicine.
Sprache der Kurzfassung:
Englisch
Journal:
Small
Volume:
7
Number:
9
Seitenreferenz:
1236-1241
Erscheinungsmonat:
3
Erscheinungsjahr:
2011
ISSN:
1613-6829
Anzahl der Seiten:
6
Reichweite:
international
Publikationstyp:
Aufsatz / Paper in nicht-referierter Fachzeitschrift
Forschungs-