Florian Reiterer, Philipp Polterauer, Guido Freckmann, Luigi Del Re,
"Identification of CGM Time Delays and Implications for BG Control in T1DM"
: IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016, Serie IFMBE Proceedings, Vol. 57, Springer, Seite(n) 190-195, 4-2016, ISBN: 978-3-319-32701-3
Original Titel:
Identification of CGM Time Delays and Implications for BG Control in T1DM
Sprache des Titels:
Englisch
Original Buchtitel:
IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016
Original Kurzfassung:
Continuous glucose monitoring (CGM) systems
are becoming increasingly popular for the management of type 1
diabetes mellitus (T1DM). However, one of the limitations of using
CGM information for blood glucose (BG) control is the fact
that the CGM sensor measures the glucose not in the blood, but
in the interstitial fluid. The current paper shows how a sensor
and patient-specific time delay between interstitial glucose (IG)
and blood glucose (BG) can be identified from CGM recordings
and BG measurements. The resulting time delay values were
found to be highly patient-specific and correlated with patient
characteristics. Furthermore, it was found that the CGM time
delays are a good predictor for the required total daily dose
(TDD) of insulin, as well as for the carbohydrate-to-insulin-ratio
(CIR). Based on these findings we introduce a method of how
insulin therapy in T1DM could possibly be adjusted based on
identified CGM time delays.