New Photo-CORMs: Deeply-coloured Biocompatible Rhenium Complexes for the Controlled Release of Carbon Monoxide
Sprache des Titels:
Air- and water-stable rhenium carbonyl complexes are investigated as CO-carriers for studying the light-dependent release of small amounts of carbon monoxide under physiological conditions. The reported quantum yields are in a suitable range for inducing beneficial therapeutic effects as photochemical CO-releasing molecules (Photo-CORMs) without rapidly reaching cytotoxic levels of carbon monoxide. Preliminary results on bio-compatibility and selective uptake of the compounds into human colon carcinoma cells (Caco-2 cell line) are described.