Publikationsdetails

Zitat:	Werner Baumgartner, Armin Osmanagic, Marita Gebhart, Sandra Krämer, Nikola Golenhofen, "Different pH-dependencies of the two synaptic adhesion molecules N-cadherin and cadherin-11 and the possible functional implication for long-term potentiation" , in Synapse, Vol. 67, Nummer 10, Seite(n) 705-715, 2013, ISSN: 1098-2396
Original Titel:	Different pH-dependencies of the two synaptic adhesion molecules N-cadherin and cadherin-11 and the possible functional implication for long-term potentiation
Sprache des Titels:	Englisch
Original Kurzfassung:	Ca(2+) -dependent adhesion molecules, cadherins, localised at synaptic sites are critically involved in long-term potentiation (LTP). N-cadherin is thought to promote LTP whereas cadherin-11 seems to counteract LTP. Since high synaptic activity is accompanied by local transient changes of the pH in the synaptic cleft, we studied whether the binding activity of cadherins is dependent on the pH and whether this might play a role during LTP. By atomic force microscopy (AFM) and laser tweezer experiments, we could show on the single molecule level as well as in a cell-based system that a decrease of the pH from 7.4 to 7.0 will result in a significant weakening of N-cadherin binding activity but in an increase of cadherin-11 binding. These differences in the pH dependencies of both molecules could be one explanation for their opposing roles during LTP. High-frequency stimulation will lead to a local acidosis in the synaptic cleft resulting in weakening of N-cadherin-mediated adhesion facilitating synaptic remodeling and LTP induction, whereas cadherin-11 bonds will be strengthened counteracting synaptic remodeling and LTP generation. Synapse 67:705-715, 2013. © 2013 Wiley Periodicals, Inc.
Sprache der Kurzfassung:	Englisch
Journal:	Synapse
Volume:	67
Number:	10
Seitenreferenz:	705-715
Erscheinungsjahr:	2013
ISSN:	1098-2396
Anzahl der Seiten:	11
DOI:	10.1002/syn.21679
Reichweite:	international
Publikationstyp:	Aufsatz / Paper in SCI-Expanded-Zeitschrift
Autoren:	Werner Baumgartner, Armin Osmanagic, Marita Gebhart, Sandra Krämer, Nikola Golenhofen
Forschungseinheiten:	Institut für Medizin- und Biomechatronik

Wissenschaftsgebiete:	Medizintechnik (ÖSTAT:206)

fodok.jku.at

Benutzerbetreuung: Sandra Winzer, letzte Änderung:

Johannes Kepler Universität (JKU) Linz, Altenbergerstr. 69, A-4040 Linz, Austria
Telefon + 43 732 / 2468 - 9121, Fax + 43 732 / 2468 - 29121, Internet www.jku.at, Impressum