Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R
In Chaps. 7 and 8, we discussed several testing procedures to detect differentially expressed genes with monotone relationship with respect to dose. The second question of primary interest in dose-response studies is the nature (or the shape of curve) of the dose-response relationship. In the context of dose-response microarray experiments, we wish to group (or classify) genes with similar dose-response relationship. Similar to the previous chapters, the subset of genes with monotone relationship is of interest.