A Water Soluble Tri-cationic Porphyrin-EDTA Conjugate induces Apoptosis in Human Neuroendocrine Tumor Cell Lines
Sprache des Titels:
In this study, a completely water soluble tri-cationic porphyrin-EDTA conjugate was
synthesized. We present data demonstrating the tumoristatic effects of the novel fully water soluble
cationic porphyrin TMPy3PhenEDTA-P-Cl4 in the dark, in the medullary thyroid carcinoma cell lines
MTC-SK and SHER-I and weaker effects in the small intestinal neuroendocrine tumor cell line KRJ-I. In
addition, cytotoxic effects were also studied in normal human fibroblasts that represent normal tissue
and the results are compared to the tumor cell lines.