HUMAN - HUman Milk vesicles Applied in neonatal NEC
Sprache der Bezeichnung:
Englisch
Original Kurzfassung:
Necrotizing Enterocolitis (NEC) is a devastating disease affecting preterm infants with a high mortality or a risk of long term sequelae. So far human milk and its components are the only known protective agent against this disease. EVs are nanosized cell communication messengers that play an important role in various biological processes, and are also being present in human milk. Previous research has shown that in-vitro and in vivo application of human EVs protected from oxidative stress-induced intestinal cell injury and the villous integrity from injury in a rat model of necrotizing enterocolitis (NEC). Therefore, the ultimate aim of this interdisciplinary project is to develop a safe and effective prevention and treatment strategy utilizing human milk EVs for preterm infants at risk or suffering from NEC trough establish cutting-edge isolation techniques that yield high-quality human milk extracellular vesicles. These vesicles will then undergo rigorous functional testing in NEC cell culture and animal models, with the future aim of enabling the clinical application of extracellular vesicles in the treatment and prevention of neonatal NEC.