Asymmetrically substituted cationic porphyrins inhibit tumor proliferation in small intestinal neuroendocrine tumors and medullary thyroid carcinomas
Sprache des Vortragstitels:
Englisch
Original Tagungtitel:
Gordon Research Conference - Chemistry & Biology of Tetrapyrroles
Sprache des Tagungstitel:
Englisch
Original Kurzfassung:
In this work we presented the synthesis of the fully water soluble cationic porphyrins TMPy3PhenEDTA-P-Cl4, TMPy3PhenIndolprot1P?Cl3 and TMPy3Py-Fluorenyl1P?Cl4 functionalized with EDTA, indole or fluorene moieties. Antiproliferative effects were evaluated in the small intestinal neuroendocrine tumor (SI-NET) cell line KRJ-I [3], the medullary thyroidcarcinoma (MTC) cell line MTC-SK [4] and the human fibroblast cell line HFSAR.